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Glutamine is the most abundant amino acid in the body, comprising more than 60% of the free amino acid pool in skeletal muscle, and greater than 20% of total circulating amino acids. During stressful situations (i.e. heavy resistive weight training) the body can lose a large amount of glutamine.
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A loss of glutamine during exercise may be a signal for protein catabolism (muscle breakdown).Glutamine supplementation has been shown to prevent the loss of body mass through the positive role glutamine plays in protein synthesis and its action as a potent anabolic agent. When muscle glutamine levels are restored in a positive nitrogen balance, muscle synthesis can return to a normal rate.
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